Abeomics/Boceprevir/1 mg/15-4001,Abeomics,,Abeomics,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Abeomics/Boceprevir/1 mg/15-4001

产品编号：15-4001

市场价：¥3600.00

场地：美国(厂家直采)

产品分类：细胞相关>细胞培养>刺激/抑制试剂>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$180.00

品牌： Abeomics

公司：Abeomics

公司分类：

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Amount :	5 mg
Purification :	≥98%
Content :	Boceprevir is supplied as a crystalline solid.
Storage condition :	Store at -20°C, product is stable for at least two years.


Alternative Name :	SCH 503034, Victrelis,

Molecular Formula:C₂₇H₄₅N₅O_5,

Molecular Weight:519.7

Boceprevir is a protease inhibitor that covalently, yet reversibly, binds (Ki = 14 nM) to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication.It was shown to inhibit the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM.1 Boceprevir can inhibit the activity of recombinant HCV genotype 1a and 1b NS3/4A protease enzymes in vitro with Ki values of 14 nM for each subtype.2 It has been evaluated in phase III clinical studies in combination with the current standard of care for treatment of HCV.

Boceprevir is supplied as a crystalline solid. A stock solution may be made by dissolving the boceprevir in the solvent of choice. Boceprevir is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of boceprevir in ethanol and DMF is approximately 25 mg/ml and approximately 16 mg/ml in DMSO.

Boceprevir is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, boceprevir should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Boceprevir has a solubility of approximately 0.14 mg/ml in a 1:6 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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品牌介绍

Abeomics Inc.致力于帮助科学家摆脱常规的动手实验室工作，从而帮助他们开展更多的创造性研究。我们通过提供定制和合同实验室服务来做到这一点，以缩短您的研发时间，并使您更快地专注于后续步骤。Abeomics由一组经验丰富的科学家组成，他们还建立了成功的全球业务，其中包括世界一流的生命科学试剂和合同实验室服务提供商IMGENEX Inc.，以及用于系统生物学和临床医学的复杂的交互式Web数据库Protein Lounge。生物信息学。

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