Abeomics/Grazoprevir/5 mg/15-4003,Abeomics,,Abeomics,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Abeomics/Grazoprevir/5 mg/15-4003

产品编号：15-4003

市场价：¥2400.00

场地：美国(厂家直采)

产品分类：分子类>其他分子产品>酶抑制剂>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$120.00

品牌： Abeomics

公司：Abeomics

公司分类：

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Amount :	10 mg
Purification :	≥98%
Content :	Grazoprevir is supplied as a crystalline solid.
Storage condition :	Store at -20°C.


Alternative Name :	MK-5172

Molecular Formula:C₃₈H₅₀N₆O₉S

Molecular Weight:766.9

Grazoprevir is a pan-genotypic protease inhibitor that binds to hepatitis C virus (HCV) non-structural protein 3/4A (NS3/4A), a serine protease essential for viral replication.Grazoprevir has potent in vitro activity against major HCV genotypes (Kis = 0.1, 0.1, 0.08, 0.15, and 0.9 nM for genotypes 1a, 1b, 2a, 2b, and 3a, respectively) and common resistance genotypes (Kis = 0.07, 0.14, and 0.30 nM for genotypes 1b R155K, D165V, and D168Y, respectively). Grazoprevir inhibits the NS3/4A protease in an in vitro replicon system with EC50 values of 2 and 8 nM for genotypes 1a and 2a, respectively. Formulations containing grazoprevir are used in combination therapies to treat HCV.

A stock solution may be made by dissolving the grazoprevir in the solvent of choice. Grazoprevir is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of grazoprevir in these solvents is approximately 15, 25, and 30 mg/ml, respectively.

Grazoprevir is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, grazoprevir should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Grazoprevir has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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品牌介绍

Abeomics Inc.致力于帮助科学家摆脱常规的动手实验室工作，从而帮助他们开展更多的创造性研究。我们通过提供定制和合同实验室服务来做到这一点，以缩短您的研发时间，并使您更快地专注于后续步骤。Abeomics由一组经验丰富的科学家组成，他们还建立了成功的全球业务，其中包括世界一流的生命科学试剂和合同实验室服务提供商IMGENEX Inc.，以及用于系统生物学和临床医学的复杂的交互式Web数据库Protein Lounge。生物信息学。

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