Abeomics/E-64d/1 mg/15-4009,Abeomics,,Abeomics,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Abeomics/E-64d/1 mg/15-4009

产品编号：15-4009

市场价：¥1800.00

场地：美国(厂家直采)

产品分类：细胞相关>细胞培养>刺激/抑制试剂>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$90.00

品牌： Abeomics

公司：Abeomics

公司分类：

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Amount :	5 mg
Purification :	≥98%
Content :	E-64d is supplied as a crystalline solid.
Storage condition :	Store at -20°C, product is stable for at least two years.


Alternative Name :	Aloxistatin, E-64c ethyl ester,EP 453, EST, Loxistatin, NSC 694281

Molecular Formula:C₁₇H₃₀N₂O₅

Molecular Weight:342.4

Cysteine proteases are a class of enzymes containing an active-site cysteine residue that is important in protein degradation pathways. E-64d, a synthetic analog of E-64 and ethyl ester of E-64c, is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases.E-64d inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. By disrupting protease activity, E-64d, at concentrations between 20-200 µM, has been shown to arrest human epidermoid carcinoma A431 cells at mitotic metaphase.It also inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 µM.

A stock solution may be made by dissolving the E-64d in the solvent of choice. E-64d is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of E-64d in ethanol is approximately 10 mg/ml and approximately 30 mg/ml in DMSO and DMF.

E-64d is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, E-64d should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. E-64d has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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品牌介绍

Abeomics Inc.致力于帮助科学家摆脱常规的动手实验室工作，从而帮助他们开展更多的创造性研究。我们通过提供定制和合同实验室服务来做到这一点，以缩短您的研发时间，并使您更快地专注于后续步骤。Abeomics由一组经验丰富的科学家组成，他们还建立了成功的全球业务，其中包括世界一流的生命科学试剂和合同实验室服务提供商IMGENEX Inc.，以及用于系统生物学和临床医学的复杂的交互式Web数据库Protein Lounge。生物信息学。

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